LD w/ meal 11 11 two 7 2 11 two 9 two 9 2Matrix 0.eight 1.5 1.5 1.six 1.six 1.six 1.six 1.six High High Higher High Higher Near optimal Higher Bdln high Bdln high High High Bdln higher Higher Optimal Higher Quite high ,50 50 ,50 .50 Sterol ester No cost sterols Stanol ester Sterol esters ,50 ,50 ,50 50 ,50 Sterol esters Sterol esters Sterol esters Sterol esters Stanol esters NR NR ,50 ,50 .50 ,50 .50 Cost-free sterol Free sterol Sterol esters Sterol esters Sterol esters Sterol esters Stanol ester 1.6 1.8 2 two 2 six 5 2 10 2 9 22Design D NS High Male .50 Stanol estersPS g/d dose Baseline LDLc Sex Type PS PS plant supply (26) a (44) a (44) b (39) e (39) b (39) a (43) a (26) b (41) (40) (57) b (77) b (27) a (77) a (70) (26) c (25) aReported LDLcReferenceMargarine 2 two NR NR NR two 2/3 2 two 2 NR two NR NR 2/3 eight 9 224wk crossoverMargarine Margarine Margarine Margarine Margarine Margarine Margarine LD BD NR NR BD NR NR w/ meal NR13wk parallel 26wk parallel 3wk parallel 3wk parallel 3wk parallel three.5wk crossover 4wk crossoverMargarine Margarine Margarine Margarine Margarine 2 2.1 two.4 2.52wk parallel 3wk crossover 3wk crossover 4wk crossover 4wk parallelMargarine Margarine Margarine NR4wk crossover 3wk crossover 4wk crossoverMargarine4wk crossoverMargarine Margarine Margarine6wk crossover 6wk crossover 8wk crossover 8 ten 22NR NR NR Bdln high Bdln higher Very highNR NR NR2.5 two.five two.0 0 ,Stanol esters Stanol esters Sterol esters(45) a (45) b (25) bMargarine Margarine Margarine Margarine 15 12 2 ten 223wk 3wk 3wk 4wk 2 two 2 two 2 two 2/3 3 three BLD BLD 3.eight 4 NR NR LD LD LD LD w/ meal three 3 three.2 three.two 3.2 three.two three.two 12 11 NS NS two 13 2 ten 22parallel parallel parallel parallelNR NR NRw/ meal w/ meal w/ meal BLD3 three 3High High Higher Bdln high High Higher Bdln high Bdln higher Bdln high Near optimal Higher 15 13 Close to optimal Close to optimal,50 ,50 .1349151-98-9 Chemical name 50 ,50 NR NR 50 50 50 ,50 .50 ,50 ,Sterol esters Sterol esters Sterol esters Stanol esters Free sterol Free of charge sterol Sterol esters Sterol esters Sterol esters Sterol esters Stanol esters Stanol esters Stanol esters(39) d (39) f (39) c (27) b (44) c (44) d (42) b (42) c (42) a (43) b (26) d (24) a (24) b (Continued)Margarine Margarine Margarine Margarine Margarine Margarine Margarine12wk parallel 26wk parallel 3.1802251-49-5 Chemscene 5wk crossover three.5wk crossover three.5wk crossover three.5wk crossover 4wk crossoverPhytosterols plus the food matrixMargarine Margarine8wk parallel 8wk parallelSitostanol (77 ), campestanol (23 ) Wood Wood Tall oil, rapeseed oil Tall oil Soybean oil Soybean oil Sitostanol (76 ), campestanol (23 ) Soybean oil Soybean oil Vegetable oil Tall oil Sitostanol (60 ) Campestanol (40 ) Rapeseed oil Rice bran oil Sitostanol (76 ), campestanol (23 ) Soybean (60 ), rapeseed (30 ), sunflower (five ) Tall oil Vegetable oil Soybean (60 ), rapeseed (30 ), sunflower (5 ) Tall oil Tall oil, rapeseed oil Soybean oil Sitostanol (60 ), campestanol (40 ) Wood Wood Rice bran oil Sheanut oil Soybean oil Soybean oil Sitostanol (76 ), campestanol (23 ) Vegetable oil WoodTABLE 1 (Continued )Matrix 1 1 1 1 1 NR 1 1 1 2 NR 1 1 2/3 1 1 2 two two 2 NR NR 2 1 two three three 2 2 NR2 2Design NR NR D D NR NR w/ meal L B w/ meal NR L w/o meal BLD L w/o meal BL BL NR w/ meal NR NR LD L w/o meal BLD BLD BD NR w/ or as a meal NR w/ or as a meal BLD 8.PMID:23880095 9 four 2.4 11 eight 17 High Higher Bdln higher ,50 .50 ,50 Sterol esters Stanols Free of charge sterols stanols Vegetable oil Soybean oil Vegetable oil 0.3 0.four 0.5 0.five 0.5 three.4 1 1.6 2 2 ,two two.8 two.eight 3 3.two 3.2 1.2 1.six two 2 2 two 1.5 2.7 1.five 1.eight 1.eight two 3.two two.4 12SC two SC 11 two 8 NS 2 SC 15 two ten two 4 2 ten 2 ten two six two 9 two 9 two five two.